Otay Mesa Hotels, San Diego

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1,673 reviews)
"Great breakfast!"
United States
Susan
The price is AU$214
includes taxes & fees
22 Mar - 23 Mar
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,006 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is AU$171
includes taxes & fees
29 Mar - 30 Mar
Quality Suites San Diego Otay Mesa

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,016 reviews)
"Great stay"
United States
jennifer
The price is AU$164
includes taxes & fees
5 Apr - 6 Apr
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,380 reviews)
"Beautiful resort! Clean, well decorated and sights are stunning - will stay again! "
Canada
Emily
The price is AU$267
includes taxes & fees
1 Apr - 2 Apr
Sheraton San Diego Resort

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,000 reviews)
"Excelente "
Mexico
Julio
Valli Hi Motel

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,789 reviews)
"Great stay! Extremely clean facility, friendly/attentive staff, beautiful location. Can’t wait to stay again!"
United States
Mary
Sycuan Casino Resort

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,651 reviews)
"Great location "
United States
Efren
The price is AU$170
includes taxes & fees
29 Mar - 30 Mar
Best Western Chula Vista/Otay Valley Hotel

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,168 reviews)
"The room was spotless and the staff were very helpful and welcoming would definitely stay here again "
United States
Raul
The price is AU$173
includes taxes & fees
29 Mar - 30 Mar
Wyndham Garden San Diego Near SeaWorld

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,532 reviews)
"Very trendy hotel. Highly recommend this place "
United States
Patricia
The price is AU$402
includes taxes & fees
8 Apr - 9 Apr
Lafayette Hotel & Club

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (598 reviews)
"Excellent!"
United States
Robert
The price is AU$279
includes taxes & fees
29 Mar - 30 Mar
SpringHill Suites by Marriott Chula Vista Eastlake

Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
13.7 km from Otay Mesa
9.4 out of 10, Exceptional, (1,005 reviews)
"Everything was great!"
United States
Michelle
The price is AU$258
includes taxes & fees
29 Mar - 30 Mar
Hampton Inn & Suites Imperial Beach San Diego

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,195 reviews)
"Location is perfect! Room super spacious with great view. "
United States
Susana
Ocean Villa Inn

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
29.1 km from Otay Mesa
8.8 out of 10, Excellent, (3,625 reviews)
"Enjoyed my stay here. "
United States
Gary
The price is AU$147
includes taxes & fees
5 Apr - 6 Apr
Kings Inn San Diego

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.2 out of 10, Wonderful, (2,081 reviews)
"Great for a quick weekend stay."
United States
Jason
The price is AU$196
includes taxes & fees
13 Apr - 14 Apr
The Rambler Hotel

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
24.3 km from Otay Mesa
7.0 out of 10, Good, (1,324 reviews)
"Good value 👏 "
United States
Mark
The price is AU$98
includes taxes & fees
24 Mar - 25 Mar
Heritage Inn La Mesa

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,055 reviews)
"Great rooms & location"
Canada
Priscilla
The price is AU$297
includes taxes & fees
29 Mar - 30 Mar
Wyndham San Diego Bayside

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,237 reviews)
"Great place and service. Will definitely stay there again. "
United States
Maria
The price is AU$189
includes taxes & fees
25 Mar - 26 Mar
Best Western Americana Inn

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,374 reviews)
"Clean room, excellent friendly staff, comfortable beds"
Canada
Shauna
The price is AU$466
includes taxes & fees
5 Apr - 6 Apr
San Diego Mission Bay Resort

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,068 reviews)
"Clean room, friendly staff, and only a 15 minute walk to Old Town. Also conveniently located close to the airport just a short shuttle drive away. "
United States
Olivia
The price is AU$223
includes taxes & fees
5 Apr - 6 Apr
Holiday Inn Express San Diego Airport - Old Town by IHG

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,751 reviews)
"Nice and clean hotel when visiting the San Diego area! We have stayed here multiple times. Located next to a nice restaurant as well."
United States
Laura
The price is AU$250
includes taxes & fees
29 Mar - 30 Mar
Best Western Plus Marina Gateway Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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